Dr. M. SaravananEmail: saravananm.sdc@saveetha.comTel: +91-9443077097

Dr. M. Saravanan

Biography:

Prof. Dr Saravanan Muthupandian has more than 21 years of Research and Teaching experience. He is presently working as a Professor, Department of Pharmacology Saveetha Dental College, SIMATS, Chennai, India, Since January 2021. He has published more than 175 research papers in peer-reviewed journals, including high impact journals The LANCET (Impact Factor: 79) and Nature (Impact Factor: 42.77) with more than 11000 citations, an h-index of 47 and an i10 index of 98 with a Cumulative impact Factor of 1600. He has published Five books and 15 book chapters., He has an Associate editor of highly reputed Q1 Journals: Frontiers in Pharmacology (Impact Factor 6.9) and Frontiers in Oncology (Impact Factor 6.2).

Education:

Post-Doctoral Training, Institute of Drug Research, Hebrew University of Jerusalem, Israel

Ph.D. Life Science (Nano-biotechnology), Sathyabama University

M.Sc. Microbiology, Madurai Kamaraj University

B.Sc. Mircrobiology, Madurai Kamaraj University

Thrust Areas: Antimicrobial Resistance (AMR); Nano-Theragnostic materials for AMR and Cancer; Nano-Biosensor Based POCT and One Health approach to Combat AMR

Research:

Antimicrobial Resistance (AMR) and Cancer have a significant role in public health by destroying the potency of the existing antibiotics and anticancer drugs. Hence, novel strategies are required to combat AMR and Cancer. Meanwhile, nanobiotechnology plays a significant role in developing alternative and more effective treatment strategies for AMR and Cancer in a current scenario. Our research team mainly focused on Biocompatible Nano-biomaterials and its controlled nano-drug delivery approaches to combat emerging and re-emerging infectious diseases and Cancer. Our particular research focus includes

  • Development of Novel biomaterials to Combat Antimicrobial Resistance (AMR) 

  • Development of Nano Theragnostic Anticancer Materials  

  • Biodegradable Polymer controlled drug delivery Approaches for AMR and Cancer.

  • Polymer-based Nanocomposites and their Biomedical Application

  • Development of Nano-Biosensor Based POCT for the Rapid Detection of Bacterial and Viral infections 

  • Synthesis of Metal oxide nanoparticles and Nanocomposites Materials for biomedical Application

Selected Recent Publications: 

  1. Ikuta, K. S., Swetschinski, L. R., Robles Aguilar, G., Sharara, F., Mestrovic, T., Gray, A. P., Davis Weaver, N., Wool, E. E., Han, C., Naghavi, M… S. Mthupandian et al., (2022). Global mortality associated with 33 bacterial pathogens in 2019: A systematic analysis for the Global Burden of Disease Study 2019. The Lancet, 400, 10369, 2221-2248, Impact Factor: 202.7

  2. AE Micah, K Bhangdia, IE Cogswell, D Lasher, B Lidral-Porter, S. Muthupandian et., al (2023) Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026, The Lancet Global Health. Impact Factor: 38.927

  3. Majeed, S., Saravanan, M., Danish, M., Zakariya, N. A., Ibrahim, M. N. M., Rizvi, E. H., NisaAndrabi, S. un, Barabadi, H., Mohanta, Y. K., & Mostafavi, E. (2023). Bioengineering of green-synthesized TAT peptide-functionalized silver nanoparticles for apoptotic cell-death mediated therapy of breast adenocarcinoma. Talanta, 253, 124026. https://doi.org/10.1016/j.talanta.2022.124026 Impact Factor: 6.556

  4. Prasad, A., Khatua, A., Kishore Mohanta, Y., Saravanan, M., Meena, R., & Ghosh, I. (2022). Low-dose exposure to phytosynthesized gold nanoparticles combined with glutamine deprivation enhances cell death in the cancer cell line HeLa via oxidative stress-mediated mitochondrial dysfunction and G0/G1 cell cycle arrest. Nanoscale, 14(29). Impact Factor: 7.79

  5. Khatua, A., Prasad, A., Behuria, H. G., Patel, A. K., Singh, M., Yasasve, M., Saravanan, M., & Meena, R. (2022). Evaluation of antimicrobial, anticancer potential and Flippase induced leakage in model membrane of Centella asiatica fabricated MgONPs. Biomaterials Advances, 138, 212855. Impact Factor: 7.3

  6. M Manjusha, M Saravanan (2022). Development of novel electrochemical based nano-biosensors for the diagnosis of oral potentially malignant disorders and oral carcinoma. Oral oncology 135, 106197 https://pubmed.ncbi.nlm.nih.gov/36252433/ . Impact Factor: 5.3

  7. Biswas, K., Mishra, A. K., Rauta, P. R., Al-Sehemi, A. G., Pannipara, M., Sett, A., Bratovcic, A., Avula, S. K., Mohanta, T. K., Saravanan, M., & Mohanta, Y. K. (2022). Exploring the Bioactive Potentials of C60-AgNPs Nano-Composites against Malignancies and Microbial Infections. International Journal of Molecular Sciences, 23(2), Impact Factor: 5.9

  8. Saravanan, M., Belete, M. A., & Madhavan, Y. (2022). Monkeypox virus outbreaks in the African continent: A new zoonotic alert – Correspondence. International Journal of Surgery (London, England), 108, 106998. https://doi.org/10.1016/j.ijsu.2022.106998. Impact Factor: 13.4

  9. M Manjusha, M Yasasve, M Saravanan (2022).Lab-on-a-chip microfluidic devices: A platform for easy, effective and early diagnosis of cancer with analysis of circulating tumour cells.International Journal of Surgery, 106906 Impact Factor: 13.4

  10. Khatua, A., Prasad, A., Behuria, H.G., Patel, A.K., Singh, M., Yasasve, M., Saravanan, M. and Meena, R., 2022. Evaluation of antimicrobial, anticancer potential and Flippase induced leakage in model membrane of Centella asiatica fabricated MgONPs. Biomaterials Advances, p.212855. IF: 7.32

  11. Lopes, B.S., Hanafiah, A., Nachimuthu, R., Saravanan M., Md Nesran, Z.N. and Patil, S., 2022. The Role of Antimicrobial Peptides as Antimicrobial and Antibiofilm Agents in Tackling the Silent Pandemic of Antimicrobial Resistance. Molecules, 27(9), p.2995. IF: 4.41

  12. Tweldemedhin, M., Saravanan M., Gebremeskel, T.K., Mehari, K., Abay, G.K., Teklu, T.G., Dhandapani, R., Paramasivam, R. and Asmelash, T., 2022. Multidrug resistance from a one health perspective in Ethiopia: A systematic review and meta-analysis of literature (2015–2020). One Health, p.100390. IF: 3.80

  13. Balakrishnan, D., Pragathiswaran, C., Thanikasalam, K., Mohanta, Y.K., Saravanan, M. and Abdellattif, M.H., 2022. Molecular Docking and In Vitro Inhibitory Effect of Polyaniline (PANI)/ZnO Nanocomposite on the Growth of Struvite Crystal: a Step Towards Control of UTI. Applied Biochemistry and Biotechnology, pp.1-15. IF: 2.92

  14. Priyadarshini, E., Meena, R., Bohidar, H.B., Sharma, S.K., Abdellattif, M.H., Saravanan, M. and Rajamani, P., 2022. Comparative In Vitro Cytotoxicity Study of Carbon Dot-Based Organometallic Nanoconjugates: Exploration of Their Cell Proliferation, Uptake, and Localization in Cancerous and Normal Cells. Oxidative Medicine and Cellular Longevity, 2022. IF: 6.54