Biography:
Dr.Rajeshkumar, Professor in Department of Pharmacology, completed his PhD in the field of Nanobiomedicine and post graduate in biotechnology. He received Young Scientist award from DST-SERB, New Delhi. He published more than 300 research and review articles in reputed international journals and more than 25 book chapters in Springer, Taylor & Francis and Elsevier publishers. He also received highly contributed paper Award by Nanoconvergence, Springer, Korea. He delivered invited and guest lecturers in many International and National conference and seminars.
Education:
Ph.D. Biotechnology, MS University
M.Sc. Biotechnology, Periyar University
B.Sc. Biochemistry, Thiruvalluvar University
Thrust Areas: Nanobiomedicine; Nanotoxicology; Nano-Dentistry and Herbal Medicine
Research:
We are preparing Nanoparticles, nanocomposites and nanoformulations for the nano-based dental products and biomedical applications such as Antimicrobial, anticancer, anti-inflammatory and antioxidant activities. Nanobiomedicine Lab attached with Aquatic nanotoxicology unit for brine shrimp toxicology, zebra fish and its embryonic toxicology studies. We are preparing Nanobased drugs for various dental applications.
Metal and Metal oxide Nanoparticles (Silver NPs, gold NPs, Zinc oxide NPs, Zirconium Oxide NPs, Selenium NPs, Copper NPs, calcium, cerium oxide, Nanohydroxyaptites etc)
Polymer nanoparticles (Chitosan, Silica etc), Polymer based metal and metal oxide nanocomposites, Nanoformulations
Herbal drugs
Antimicrobial activity including (Antibacterial and antifungal activity against oral, gastro intestinal, urinary tract infection and many clinical pathogens) (including mechanism action)
Nano-dentistry
Toxicological activity (Zebra fish and Animal model)
Wound healing activity and Tissue Engineering
Selected Recent Publications:
1. S. Rajeshkumar, J. Santhoshkumar, M. Vanaja, P. Sivaperumal, M. Ponnanikajamideen, Daoud Ali, Kalirajan Arunachala m, "Evaluation of Zebrafish Toxicology and Biomedical Potential of Aeromonas hydrophila Mediated Copper Sulfide Nanoparticles", Oxidative Medicine and Cellular Longevity, vol. 2022, Article ID 7969825, 12 pages, 2022. https://doi.org/10.1155/2022/7969825. IF : 7.310
2. Balusamy, S.R., Rahimi, S., Sukweenadhi, J., Sunderraj, S., Shanmugam, R., Thangavelu, L., Mijakovic, I. and Perumalsamy, H., 2022. Chitosan, chitosan nanoparticles and modified chitosan biomaterials, a potential tool to combat salinity stress in plants. Carbohydrate Polymers, p.119189. https://doi.org/10.1016/j.carbpol.2022.119189. IF: 10.731
3. Mi, Xiao-jie, Han Sol Choi, Haribalan Perumalsamy, Rajeshkumar Shanmugam, Lakshmi Thangavelu, Sri Renukadevi Balusamy, and Yeon-Ju Kim. "Biosynthesis and cytotoxic effect of silymarin-functionalized selenium nanoparticles induced autophagy mediated cellular apoptosis via downregulation of PI3K/Akt/mTOR pathway in gastric cancer." Phytomedicine (2022): 154014. IF : 6.656
4. Jayakodi, Santhoshkumar, Rajeshkumar Shanmugam, Bader O. Almutairi, Mikhlid H. Almutairi, Shahid Mahboob, M. R. Kavipriya, Ramesh Gandusekar, Marcello Nicoletti, and Marimuthu Govindarajan. "Azadirachta indica-wrapped copper oxide nanoparticles as a novel functional material in cardiomyocyte cells: An ecotoxicity assessment on the embryonic development of Danio rerio." Environmental Research (2022): 113153. IF: 8.431.
5. Jose, J.; Teja, K.V.; Janani, K.; Alam, M.K.; Khattak, O.; Salloum, M.G.; Magar, S.S.; Magar, S.P.; Rajeshkumar, S.; Palanivelu, A.; et al. Preparation of a Novel Nanocomposite and Its Antibacterial Effectiveness against Enterococcus faecalis—An In Vitro Evaluation. Polymers 2022, 14, 1499. https:// doi.org/10.3390/polym14081499. IF: 4.967
6. Dhanraj Ganapathy, Rajeshkumar Shanmugam, Sivaperumal Pitchiah, Preethika Murugan, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kaliannan Durairaj, Ashok K. Sundramoorthy, "Potential Applications of Halloysite Nanotubes as Drug Carriers: A Review", Journal of Nanomaterials, vol. 2022, Article ID 1068536, 7 pages, 2022. https://doi.org/10.1155/2022/1068536. IF: 3.791.
7. M. Nagalingam, S. Rajeshkumar, Satheesh Kumar Balu, M. Tharani, Kalirajan Arunachalam, "Anticancer and Antioxidant Activity of Morinda Citrifolia Leaf Mediated Selenium Nanoparticles", Journal of Nanomaterials, vol. 2022, Article ID 2155772, 7 pages, 2022. https://doi.org/10.1155/2022/2155772. IF: 3.791.
8. Haribalan Perumalsamy, Rajeshkumar Shanmugam, Jun-Ran Kim, Gokulanathan Anandapadmanaban, Md. Amdadul Huq, Kamal Dua, Dinesh Kumar Chellappan, Tae Hyun Yoon, Sri Renukadevi Balusamy, "Nanoemulsion and Encapsulation Strategy of Hydrophobic Oregano Essential Oil Increased Human Prostate Cancer Cell Death via Apoptosis by Attenuating Lipid Metabolism", Bioinorganic Chemistry and Applications, vol. 2022, Article ID 9569226, 11 pages, 2022. https://doi.org/10.1155/2022/9569226. IF: 7.778
9. Garapati, B., Malaiappan, S., Rajeshkumar, S. and Murthykumar, K., Cytotoxicity of lycopene‐mediated silver nanoparticles in the embryonic development of zebrafish—An animal study. Journal of Biochemical and Molecular Toxicology, p.e23173. IF: 3.568
10. S. Rajeshkumar, R. P. Parameswari, J. Jayapriya, M. Tharani, Huma Ali, Nada H. Aljarba, Saad Alkahtani, Saud Alarifi, "Apoptotic and Antioxidant Activity of Gold Nanoparticles Synthesized Using Marine Brown Seaweed: An In Vitro Study", BioMed Research International, vol. 2022, Article ID 5746761, 9 pages, 2022. https://doi.org/10.1155/2022/5746761. IF: 3.426
11. Shanmugam Rajeshkumar, Jayakodí Santhoshkumar, R. P. Parameswari, S. Saravanan, Sri Renukadevi Balusamy, Kalirajan Arunachalam, "Degradation of Toxic Dye and Antimicrobial and Free Radical Potential of Environmental Benign Zinc Oxide Nanoparticles", Bioinorganic Chemistry and Applications, vol. 2022, Article ID 4513208, 10 pages, 2022. https://doi.org/10.1155/2022/4513208. IF: 7.778
12. S. Rajeshkumar, Hanen Sellami, Daoud Ali, S. Chitra, M. Ponnanikajamideen, Kalirajan Arunachalam, "Bioconjugation of Fluorescent Gold Nanoparticles Synthesized Using Marine Brown Algae Sargassum longifolium", Journal of Nanomaterials, vol. 2022, Article ID 6765227, 9 pages, 2022. https://doi.org/10.1155/2022/6765227. IF: 3.791
13. Sundar, S.; Ramadoss, R.; Shanmugham, Rajeshkumar.; Anandapadmanabhan, L.T.; Paneerselvam, S.; Ramani, P.; Batul, R.; Karobari, M.I. Salivary Antibody Response of COVID-19 in Vaccinated and Unvaccinated Young Adult Populations. Vaccines 2022, 10, 1819. https://doi.org/10.3390/ vaccines10111819. IF: 5.325.