Dr. senthilkumar krishnamoorthi

Biography:

Dr. Senthilkumar Krishnamoorthi has completed his Ph.D. in Biochemistry-Endocrinology at the University of Madras. He was a Postdoctoral Research Fellow at the Hong Kong Baptist University, Hong Kong (SAR), China. He has 16 years of experience in research and his area of research in the field of Bone Biology and Neuroscience. He has published in more than 20 international reputed journals with high impact factors.

Education:

  • Ph.D. Biochemistry-Endocrinology, University of Madras

  • M.Phil. Endocrinology, University of Madras

  • M.Sc. Biochemistry, Thiruvalluvar University

  • B.Sc. Biochemistry, University of Madras

Research Thrust Areas:

  • Bone Biology

  • Neurosciences

Selected Recent Publications: 

  1. Tsz Yan Fung, Ashok Iyaswamy 1, Sravan G Sreenivasmurthy , Senthilkumar Krishnamoorthi , Xin-Jie Guan, Zhou Zhu, Cheng-fu Su, Jia Liu , Yuxuan Kan, Yuan Zhang , Hoi Leong Xavier Wong , Min Li. Klotho an Autophagy Stimulator as a Potential Therapeutic Target for Alzheimer’s Disease: A Review. Biomedicine 2022 Mar 18;10(3):705 doi: 10.3390/biomedicines10030705. (IF - 6.08).

  2. Ashok Iyaswamy, Xueli Wang, Senthilkumar Krishnamoorthi, Venkatapathy Kaliamoorthy, Siva Sundara Kumar Durairajan, Ju-Xian Song, Benjamin Chun-kit Tong, Sravan G. Sreenivasmurthy, Zhou Zhu, Cheng-Fu Su, Jia Liu,  King-Ho Cheung, Jia-Hong Lu, Jie-Qiong Tan,  Hung-Wing Li, Man Shing Wong and Min Li. Theranostic F-SLOH mitigates Alzheimer’s disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer’s disease models. Redox Biology (2022). doi: 10.1016/j.redox.2022.102280 (IF - 11.8).

  3. Sravan Gopalkrishna Shetty Sreenivasmurthy, AshokIyaswamy, Senthilkumar Krishnamoorthi, Sanjib Senapati , Sandeep Malampati, Zhou Zhu ,Cheng-FuSu , JiaLiu, Xin-Jie Guan,  Benjamin Chun-KitTong, King-Ho Cheung, Ji -Qiong T and Jia-Hong Lu, Siva Sundara Kmar Durairajan, Ju-XianSong and Min Li. Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition. Phytomedicine 96 (2022) 153887. (IF - 5.34).

  4. Chuanbin Yang, Chengfu Su, Ashok Iyaswamy, SenthilKumar Krishnamoorthi, Zhou Zhu, Sichang Yang, Benjamin Chunkit Tong, Jia Liu, Sravan G. Sreenivasmurthy, Xinjie Guan, Yuxuan Kan, Aston Jiaxi Wu, Alexis Shiying Huang, Jieqiong Tan, Kingho Cheung, Juxian Song, Min Li Celastrol Enhances Transcription Factor EB (TFEB)-mediated Autophagy and Mitigates Tau Pathology: Implications for Alzheimer's Disease Therapy. Acta Pharmaceutica Sinica B (2021) (IF - 11.413). 

  5. Ashok Iyaswamy, Senthil Kumar Krishnamoorthi, Huan Zhang, Sravan G. Sreenivasmurthy, Zhou Zhu, Jia Liu, Cheng-Fu Su, Xin-Jie Guan, Zi-Ying Wang, King-Ho Cheung, Ju-Xian Song, Siva Sundara Kumar Durairajan, Min Li.  Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer’s disease. Phytomedicine 91 (2021) 153648. (IF - 5.34).

  6. Tong BCK, Wu JX, Huang SY, Dong R, Malampati S, Iyaswamy A, Krishnamoorthi SK, Sreenivasmurthy SG, Zhu Z, Su CF, Liu J, Song JX, Lu JH, Tan JQ, Pan WD, Li M & Cheung KH (2021). “Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease”. Autophagy, 2021, 1-19. (IF - 16.02).

  7. Yang CB, Liu J, Tong BCK, Wang ZY, Zhu Z, Su CF, Sreenivasmurthy SG, Wu JX, Iyaswamy A, Krishnamoorthi SK, Huang SY, Cheung KH, Song JX, Tan JQ, Lu JH, Li M (2021). “TFEB, a master regulator of autophagy and biogenesis, unexpected promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2”. Acta Pharmacologica Sinica. (IF - 6.15).

  8. Iyaswamy A, Krishnamoorthi SK, Liu YW, Song J-X, Kammala AK, Sreenivasmurthy SG, Malampati S, Tong BCK, Selvarasu K, Cheung KH, Lu JH, Tan JQ, Huang CY, Durairajan SSK and Li M.  Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease. Front. Pharmacol., 2020,11:584770. doi:10.3389/fphar.20 20.584770. (IF - 5.81).

  9. Ashok Iyaswamy, Senthil Kumar Krishnamoorthi, Ju-Xian Song, Chuan-Bin Yang, Venkatapathy Kaliyamoorthy, Huan Zhang, Sravan G. Sreenivasmurthy, Sandeep Malampati, Zi-Ying Wang, Zhou Zhu, Benjamin Chun-Kit Tong, King-Ho Cheung, Jia-Hong Lu, Siva Sundara Kumar Durairajan, Min Li. NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models, Journal of Food and Drug Analysis, 28, (1), 2020,132-146. https://doi.org/10.1016/j.jfda.2019.09.004. (IF - 6.079).

  10. Xueli Wang, Chengke Wang, Hei-Nga Chan, Iyaswamy Ashok, Senthilkumar Krishnamoorthi, Min Li, Hung-Wing Li, Man Shing Wong. Amyloid-β oligomer targeted theranostic probes for in vivo NIR imaging and inhibition of self-aggregation and amyloid-β induced ROS generation. Talanta, 2020, https://doi.org/10.1016/ j. Talanta.2020.121830. (IF - 6.057).

  11. Ng RC, Jian M, Ma OK, Bunting M, Kwan JS, Zhou GJ, Senthilkumar K, Iyaswamy A, Chan PK, Li M, Leung KM, Kumar Durairajan SS, Lam KS, Chu LW, Festenstein R, Chung SK, Chan KH. Chronic oral administration of adipoRon reverses cognitive impairments and ameliorates neuropathology in an Alzheimer’s disease mouse model. Molecular Psychiatry, 2020. https://doi.org/ 10.1038/s41380-020-0701-0. (IF - 15.992).

  12. Yang C, Zhu Z, Tong BC, Iyaswamy A, Xie WJ, Zhu Y, Sreenivasmurthy SG, Senthilkumar K, Cheung KH, Song JX, Zhang HJ, Li M. A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38. Redox Biology, 2020. https://doi.org/10.1016/j.redox.2020.101445. (IF - 11.8)