“Silver nanoparticles coated catheter- A new approach for combating AMR”
Fighting Infections
Silver nanoparticles coated catheter
Antimicrobial resistance (AMR) threatens the effective prevention and treatment of an ever-increasing range of infections Including urinary tract infections (UTI). Rising incidents of AMR biofilm forming UTIs among catheterized patients is a noteworthy problem in clinic due to their colonization of uropathogens on abiotic surfaces. AMR and Nanomedicine lab have examined the surface modification of urinary catheter by embedding with eco-friendly synthesized phytomolecules-capped silver nanoparticles (AgNPs) and its prove it to prevent the invasion and colonization of biofilm producing uropathogens. To determine the Antibacterial /Antibiofilm activity of AgNPs coated catheter and Synergistic effect of AgNPs with antibiotic was assessed. Synergistic effect of AgNPs with antibiotic reveals that it can enhance the activity of antibiotics, AgNPs coated catheter revealed that, it has potential antimicrobial and antibiofilm activity.
This research will open a new avenue and a promising nano-materials to embed on catheter and biomedical devices to control biofilm forming clinical pathogens. Thus, the present study helps in disclosing the biomaterial coating acts as a preventive shield against uropathogens and it is long lasting, feasible technique and it act as promising treatment for UTI and nosocomial infections. The results were published very recently in the PLOS ONE. For more information on the research details click https://doi.org/10.1371/journal.pone.0256748