Dr. P. ElumalaiEmail: elumalai.sdc@saveetha.comTel: +91-9344430294

Dr. P. Elumalai

Biography:

Dr. P. Elumalai has completed his M.Sc and PhD in Biomedical Science-Endocrinology at University of Madras. He was a Research Professor and Postdoctoral Fellow at the Catholic University of Korea, Seoul, South Korea. He has 14 years of research experience in cancer and Molecular Biology. He has published more than 30 research articles in reputed international journals including high impact Journals Cell Proliferation (IF: 6.83) and Clinical Nutrition (IF: 7.32) with more than 1330 citations and h-index of 23 and i10 index of 28 with a Cumulative impact Factor of 115. He has published 3 book chapters. He has been awarded several fellowships like PBC outstanding Postdoctoral fellowship in Israel, CSIR-SRF and UGC-Project Fellow in India.

Education:

Post-Doctoral Fellowship, The Catholic University of Korea, South Korea

Ph.D. Biomedical Science-Endocrinology, University of Madras

M.Sc. Biomedical Sciences, University of Madras

B.Sc. Zoology, University of Madras

Thrust Areas: Cancer Genomics; CRISPR/Cas9 technology; Tumor microenvironment; Anti-cancer drug discovery and Stem Cell Research

Research:

He has a strong background in molecular biology and cancer genomics. His research involves understanding how epithelial to mesenchymal transition signalling molecules are regulated in cancer metastasis. His post-doctoral research work is on Patient Derived Xenograft model, for the precision medicine approach and developed more than ten primary cancer cell lines from human cancer tissue and PDX tumor tissue. Further, his research group investigated the role of EMT related genes in lung and ovarian cancer progression using Single cell RNA sequencing and 3D culture system. And also he investigated the CRISPR/Cas9 mediated PTEN knockout and its impact on epithelial to mesenchymal transition and metastasis of lung cancer cells. He also studied the molecular mechanisms on the chemopreventive effect of nimbolide in breast cancer cell lines for his doctoral research. Currently, he is working on dental mesenchymal stem cells-based therapeutic approaches for dental diseases and also doing cytotoxicity and biocompatibility studies for the various biomaterials using periodontal ligament and gingival derived primary fibroblast cells. 

  1. Cancer genomics: Genome editing using CRISPR/Cas9 technology to study the signalling pathways and molecular mechanisms in the tumour microenvironment.

  2. Anti-cancer drug discovery: Development of anti-cancer drug from the Indian traditional medicinal plant based compounds.

  3. Stem Cell Research: Development of regenerative therapeutic strategies in Development of regenerative therapeutic strategies in dental medicine using gingival, periodontal ligament and dental pulp derived mesenchymal stem cells. 

Selected Recent Publications: 

  1. Subramanian, K., Balaraman, D., Panangal, M., Nageswara Rao, T., Elumalai Perumal., Kumarappan, A., Sampath Renuga, P., Arumugam, S., Thirunavukkarasu, R., Aruni, W. and Yousef AlOmar, S., 2022. Bioconversion of chitin waste through Stenotrophomonas maltophilia for production of chitin derivatives as a Seabass enrichment diet. Scientific Reports, 12(1), pp.1-11. IF: 4.38

  2. Elumalai, P., Ezhilarasan, D. and Lakshmi, T., 2022. Targeting head and neck cancer epigenetics with CRISPR-dCas9: An emerging therapeutic approach. Oral Oncology, 127, pp.105801-105801. IF: 5.33

  3. Elumalai Perumal, Devaraj Ezhilarasan, and Subramanian Raghunandhakumar. "Quercetin Inhibits the Epithelial to Mesenchymal Transition through Suppressing Akt Mediated Nuclear Translocation of Β-Catenin in Lung Cancer Cell Line." Nutrition and Cancer  (2021): 1-13. IF: 3.51

  4. Yin, Jing Hu, Elumalai Perumal, So Youn Kim, Song Zi Zhang, Sun Shin, Minho Lee, and Yeun-Jun Chung. "Tnnc1 Knockout Reverses Metastatic Potential of Ovarian Cancer Cells by Inactivating Epithelial-Mesenchymal Transition and Suppressing F-Actin Polymerization." Biochemical and Biophysical Research Communications 547 (2021): 44-51. IF: 3.57

  5. Paramasivam, Arumugam, Jayaseelan Vijayashree Priyadharsini, Subramanian Raghunandhakumar, and Elumalai Perumal. "A Novel Covid-19 and Its Effects on Cardiovascular Disease." Hypertension Research 43, no. 7 (2020): 729-30. IF: 3.87

  6. Elumalai Perumal, Kim So Youn, Shin Sun, Jung Seung-Hyun, Min Suji, Liu Jieying, and Chung Yeun-Jun. "Pten Inactivation Induces Epithelial-Mesenchymal Transition and Metastasis by Intranuclear Translocation of Β-Catenin and Snail/Slug in Non-Small Cell Lung Carcinoma Cells." Lung Cancer 130 (2019): 25-34. IF: 5.7

  7. Balakrishnan, S, FA Bhat, P Raja Singh, S Mukherjee, P Elumalai, S Das, CR Patra, and J Arunakaran. "Gold Nanoparticle–Conjugated Quercetin Inhibits Epithelial–Mesenchymal Transition, Angiogenesis and Invasiveness Via Egfr/Vegfr‐2‐Mediated Pathway in Breast Cancer." Cell proliferation 49, no. 6 (2016): 678-97. IF: 6.83

  8. Sharmila, G, FA Bhat, R Arunkumar, P Elumalai, P Raja Singh, K Senthilkumar, and J Arunakaran. "Chemopreventive Effect of Quercetin, a Natural Dietary Flavonoid on Prostate Cancer in in Vivo Model." Clinical nutrition 33, no. 4 (2014): 718-26. IF: 7.32

  9. Bhat, Firdous Ahmad, G Sharmila, S Balakrishnan, R Arunkumar, P Elumalai, S Suganya, P Raja Singh, N Srinivasan, and J Arunakaran. "Quercetin Reverses Egf-Induced Epithelial to Mesenchymal Transition and Invasiveness in Prostate Cancer (Pc-3) Cell Line Via Egfr/Pi3k/Akt Pathway." The Journal of Nutritional Biochemistry 25, no. 11 (2014): 1132-39. IF: 6.04

  10. Elumalai, P, A Brindha Mercy, R Arunkamar, G Sharmila, FA Bhat, S Balakrishnan, P Raja Singh, and J Arunakaran. "Nimbolide Inhibits Invasion and Migration, and Down‐Regulates Upar Chemokine Gene Expression, in Two Breast Cancer Cell Lines." Cell proliferation 47, no. 6 (2014): 540-52. IF: 6.83

  11. Elumalai Perumal, Ramachandran Arunkumar, Chellakkan Selvanesan Benson, Govindaraj Sharmila, and Jagadeesan Arunakaran. "Nimbolide Inhibits Igf‐I‐Mediated Pi3k/Akt and Mapk Signalling in Human Breast Cancer Cell Lines (Mcf‐7 and Mda‐Mb‐231)." Cell biochemistry and function 32, no. 5 (2014): 476-84. IF: 3.6

  12. Elumalai P, DN Gunadharini, K Senthilkumar, S Banudevi, R Arunkumar, CS Benson, G Sharmila, and J Arunakaran. "Induction of Apoptosis in Human Breast Cancer Cells by Nimbolide through Extrinsic and Intrinsic Pathway." Toxicology letters 215, no. 2 (2012): 131-42. IF: 4.37